Pwodwi Entwodiksyon
| Methyl p-toluenesulfonate Enfòmasyon de baz |
| Non pwodwi: | Methyl p-toluensulfonate |
| Sinonim: | 4-methyl-benzenesulfonicacimethylester;Benzenesulfonicacid,4-methyl-,methylester;Methyl 4-methylbenzenesulfonate;Methyl ester nan 4-methylbenzenesulfonic acid;Methyl para-toluenesulfonate;p-toluenesulfonate;p-toluenesulfonate; -Toluolsulfonsaeure methyl ester;p-toluolsulfonsaeuremethylester |
| CAS: | 80-48-8 |
| MF: | C8H10O3S |
| mw: | 186.23 |
| EINECS: | 201-283-5 |
| Kategori pwodwi: | Blòk Konstriksyon;Sentèz Chimik;Blòk Konstriksyon òganik;Konpoze souf;Blòk konstriksyon òganik;Konpoze souf;Tosilat;bc0001;80-48-8 |
| Mol File: | 80-48-8.mol |
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| Methyl p-toluenesulfonate Pwopriyete Chimik |
| Pwen k ap fonn | 25-28 degre (lit.) |
| Pwen bouyi | 144-145 degre 5 mm Hg(lit.) |
| dansite | 1.234 g/mL nan 25 degre (limen) |
| dansite vapè | 6.45 (kont lè) |
| presyon vapè | 1 mm Hg (20 degre) |
| endèks refraktif | n20/D 1.5172(lit.) |
| Fp | >230 degre F |
| tanperati depo. | 2-8 degre |
| solubilite | Chloroform (yon ti kras), metanol (yon ti kras) |
| fòm | Likid oswa solid k ap fonn ki ba |
| koulè | Blan a jòn |
| Solibilite dlo | Ensolubl |
| Sansib | Sansib imidite |
| BRN | 609209 |
| LogP | 1.88 nan 25 degre |
| Referans baz done CAS | 80-48-8(Referans baz done CAS) |
| Referans Chimi NIST | Asid benzènsulfonik, 4-methyl-, methyl ester (80-48-8) |
| Sistèm Rejis Sibstans EPA | Asid benzènsulfonik, 4-methyl-, methyl ester (80-48-8) |
| Enfòmasyon sou Sekirite |
| Kòd danje | C, Xn |
| Deklarasyon Risk | 22-34-43-40-36/37/38 |
| Deklarasyon Sekirite | 26-36/37/39-45-24 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Almay | 3 |
| RTECS | XT7000000 |
| F | 21 |
| Tanperati Autoignition | 896 degre F |
| TSCA | Wi |
| HazardClass | 8 |
| PackingGroup | III |
| Kòd HS | 29051900 |
| Done Sibstans Danjere | 80-48-8(Done Sibstans Danjere) |
| Toksisite | LD50 oralman nan lapen: 341 mg/kg |
| Enfòmasyon MSDS |
| Founisè | Lang |
|---|---|
| Methyl p-tosylate | angle |
| SigmaAldrich | angle |
| ACROS | angle |
| ALFA | angle |
| Methyl p-toluenesulfonate Itilizasyon ak sentèz |
| Pwopriyete chimik | blan a yon ti kras jòn ki ba fonn solid. Soluble nan alkòl, etè, benzèn, ensolubl nan dlo. Igroskopik. |
| Itilizasyon | Methyl p-Toluenesulfonate ka itilize nan envantè de koloran ak sentèz òganik, epi tou li se matyè premyè nan methylation. |
| Itilizasyon | Methyl p-toluenesulfonate yo itilize kòm yon ajan methylating nan sentèz òganik. Li aji kòm yon katalis pou rezin alkid. Li se tou anplwaye nan reyaksyon selektif 1-sibstitisyon tetrazol. Anplis de sa, li se itilize nan preparasyon an nan koloran. |
| Preparasyon | Methyl p-toluenesulfonate te sentèz pa reyaksyon an nan klori p-toluenesulfonyl ak metanol. Melanje p-toluenesulfonyl klori ak methanol, ajoute dousman 25% solisyon idroksid sodyòm, kontwole tanperati ki anba a 25 degre, sispann ajoute alkali lè pH la se 9, kontinye brase pou 2 èdtan, epi kite lannwit lan. Kouch ki pi ba a nan reyaktif te pran, kouch siperyè a te ekstrè ak benzèn, ekstrè a te refè ak benzèn ak Lè sa a, konbine avèk kouch ki pi ba a, lave ak dlo ak 5% solisyon kabonat potasyòm nan vire, seche ak distile anba presyon redwi jwenn pwodwi a fini nan methyl p-toluenesulfonate. |
| Referans sentèz (yo) | Bilten Chimik ak Famasetik, 29, p. 623, 1981DOI:10.1248/cpb.29.623 Kominikasyon sentetik, 15, p. 1057, 1985DOI: 10.1080/00397918508076842 |
| Deskripsyon jeneral | Methylp-toluenesulfonate se sulfonate ester prezan kòm enpurte potansyèlman genotoksik nan sibstans dwòg. Sinetik reyaksyon nan methylp-toluenesulfonate akN,N-dimethylaniline te envestige. Li patisipe nan reyaksyon selektif 1-sibstitisyon tetrazol. |
| Danje | Toksik pa enjèstyon ak rale, fò irite pou po ak je. |
| Pwofil sekirite | Pwazon pa enjèstyon ak wout lar. Yon je ak po grav irite. Yon vesicant ak sansibilize po. Kanserojèn dout ak done eksperimantal tumorigenic. Lè chofe pou dekonpozisyon li emèt lafimen toksik nan SOx. |
| Metòd pou pirifye | Estè a pirifye pa distilasyon nan vacuo epi li ka kristalize nan etè bèt kay oswa Et2O / etè bèt kay nan tanperati ki ba. Li se yon ajan methylating pwisan, se TOXIK ak se yon irite po, kidonk li se pi bon pirifye li pa distilasyon repete. [IR: Schreiber Anal Chem 21 1168 1949, Buehler et al. J Org Chem 2 167 1937, Roos et al. Org Synth Coll Vol I 145 1948, Beilstein 11 IV 247.] |
| Methyl p-toluenesulfonate Preparasyon pwodwi ak matyè premyè |
| Matyè premyè | Tosyl chloride-->4-methylbenzenediazonium tetrafluoroborate-->Tetrabutylammonium 4-toluenesulfonate-->[Hydroxy(tosyloxy)iodo]benzene-->4-Toluenesulfonyl bromide-->2,2,2-TRIFLUOROETHYL METHYL ETHER-->DIMETHYLZINC-->Trimethyl orthoacetate |
| Preparasyon pwodwi yo | 1,3,3-Trimethyl-2-methyleneindoline-->5-BROMO-1,2-DIMETHYL-1H-IMIDAZOLE-->2,5-diphenylthiazole-->3,5-Bis(2-cyanoprop-2-yl)toluene-->1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene-->2-NONYNE-->METHYL FLUORIDE-->METHYL 3,5-DIMETHYLBENZOATE-->2-CHLORO-1-METHYLPYRIDINIUM P-TOLUENESULFONATE-->ETHYL METHYL ETHER-->3,6-diamino-2,7,10-trimethylacridinium chloride-->Debaz Orange 5 |
Baj popilè: methyl p-toluenesulfonate, Lachin methyl p-toluenesulfonate manifaktirè, Swèd, faktori
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