Pwodwi Entwodiksyon
| 4-Bromethyl-2-cyanobiphenyl Enfòmasyon de baz |
| Non pwodwi: | 4-Bromethyl-2-cyanobiphenyl |
| Sinonim: | 2-CYANO-4'-BROMOMETHYLBIPHENYL;2-({4-BROMO-METHYLFENIL) BENZONITRILE;OTBNBR;{4-BroMoMethyl-2-cyanophenyl;bromoethylcyanobiphenyl;{ {8}}Bromethyl-2'-Cyano Biphenyl 2-Syano-4'-Bromomethyl Biphenyl;{4-Bromethyl{-2'-cyanobiphene;Sartan Bromo biphenyl |
| CAS: | 114772-54-2 |
| MF: | C14H10BrN |
| mw: | 272.14 |
| EINECS: | 601-327-7 |
| Kategori pwodwi: | API entèmedyè;Seri Sartan;Entèmedyè chimik pou Sartan;pharmacetical;INTERMEDIATESOF;Biphenyl & Diphenyl etè;Biphenyl dérivés;Hypertension;Entèmedyè Irbesartan;Irbesartan;Aromatik;Blòk bilding;C10 to C27;Sintez chimik;Entèmedyè chimik;P Cyanides/Nitril;Kristal likid;Syans Materyèl;Konpoze Azòt;Elektwonik òganik ak enprime;Blòk konstriksyon òganik;syanid| alkil bromur;1;114772-54-2 |
| Mol File: | 114772-54-2.mol |
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| 4-Bromethyl-2-cyanobiphenyl Pwopriyete Chimik |
| Pwen k ap fonn | 125-128 degre (lit.) |
| Pwen bouyi | 413.2±38.0 degre (Prevwa) |
| dansite | 1.43±0.1 g/cm3 (Prevwa) |
| presyon vapè | 0.1-0.2Pa nan 20-25 degre |
| tanperati depo. | Kenbe nan yon kote ki fè nwa, sele nan sèk, Tanperati chanm |
| Solibilite dlo | Ensolubl nan dlo |
| solubilite | Acetonitrile (yon ti kras), klowofò (yon ti kras) |
| fòm | poud nan kristal |
| koulè | Blan prèske blan |
| InChI | InChI=1S/C14H10BrN/c15-9-11-5-7-12(8-6-11)14-4-2-1-3-13(14)10-16/h1-8H,9H2 |
| InChiKey | LFFIEVAMVPCZNA-UHFFFAOYSA-N |
| SOURI | C1(C2=CC=C(CBr)C=C2)=CC=CC=C1C#N |
| LogP | 3.2 |
| Referans baz done CAS | 114772-54-2(Referans baz done CAS) |
| Enfòmasyon sou Sekirite |
| Kòd danje | Xi, Xn, N |
| Deklarasyon Risk | 20/21/22-36/37/38-50/53-43 |
| Deklarasyon Sekirite | 26-36/37-36/37/39-61-60 |
| RIDADR | 3439 |
| WGK Almay | 3 |
| Nòt danje | Iritant |
| HazardClass | 6.1 |
| Kòd HS | 29269090 |
| Enfòmasyon MSDS |
| Founisè | Lang |
|---|---|
| ACROS | angle |
| SigmaAldrich | angle |
| 4-Bromethyl-2-cyanobiphenyl Itilizasyon ak sentèz |
| Deskripsyon | 4-Bromethyl-2-cyanobiphenyl se yon enpòtan pharmaceutique entèmedyè ak òganik materyèl sentetik yo itilize nan preparasyon an nan dwòg nan klas la sartan tankou azilsartan ester ak temisartan. Li se tou itilize nan sentèz la nan lòt pirazolin ak dérivés ki gen rapò. Anplis de sa, dènyèman te rapòte etid sou wòl 4-Bromethyl-2-cyanobiphenyl nan detèminasyon potansyèl enpurte jenotoksik nan temesartan lè l sèvi avèk teknik ESI-MS/MS ak etid tèmodinamik nan solvang diferan.[1-2]. |
| Pwopriyete chimik | 4-Bromethyl-2-cyanobiphenyl se poud krèm |
| Itilizasyon | 4-Bromometil-2-syanobifenil yo itilize nan etid antagonis reseptè kinoxaline angiotensin II ki gen rapò ak pwoteyin yo. |
| Sentèz | 4-Bromethyl-2-cyanobiphenyl sentèz lè l sèvi avèk 2-cyano-4-methylbiphenyl kòm yon matyè premyè pa reyaksyon chimik. Etap espesifik sentèz yo se jan sa a: Yon metòd pou prepare dibromohydantoin ki baze sou tanperati nòmal bromosartan biphenyl. Fonn 10g 2-cyano-4-methylbiphenyl nan 30mL diklorometan epi mete l nan tib sereng A; ajoute 9g dibromo Hydantoin te fonn nan 30 mL nan dichloromethane epi mete nan tib la sereng B. Enstale de sereng A ak B yo sou ponp sereng koule a epi rasanble yo. Mete vitès koule de tib A ak B yo sou 1.5 mL/min. Limen aparèy beny dlo a tanperati konstan, chofe a 50 degre, kenbe tanperati a, limen 4000K limyè ki ap dirije ak limyè 475nm pou 30 minit, epi limen raktor a koule an menm tan. Apre reyaksyon an fini, ajoute 15g bisulfit sodyòm nan pwodwi k ap resevwa a pou pasè, separe likid yo, retire sòlvan an pa evaporasyon rotary nan faz òganik la, ajoute etè izopropil pou rekristalize, filtre ak aspirasyon, epi mete gato filtre a nan yon. fou pou jwenn yon pwodwi pi. Pwodwi 4-Bromethyl-2-cyanobiphenyl gen yon pite 90% ak yon sede 94%.  |
| Referans | [1] MANIKANTH REDDY YARALA; Sowjanya G. Detèminasyon potansyèl enpurte jenotoksik (Orthophenylene Diamine Dihydrochloride), 4'-Bromomethyl -2- Cyanobiphenyl, 4' (Dibromomethyl) [1,1'-Biphenyl] -2- Karbonitrile nan Telmisartan pa ESI-MS /MS.[J]. Journal of syans kwomatografik, 2023. DOI:10.1093/chromsci/bmab139. [2] JINGXIANG YANG . Thermodinamik 4'-bromomethyl-2-cyanobiphenyl nan solvang diferan [J]. Journal of Chimik Thermodinamik, 2015. DOI:10.1016/j.jct.2014.12.002. |
| 4-Bromethyl-2-cyanobiphenyl Preparasyon pwodwi ak matyè premyè |
| Preparasyon pwodwi yo | 4-(2-Cyanophenyl)benzaldehyde-->4'-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1'-Biphenyl]-2-carbonitrile-->L-VALINE, N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-, METHYL ESTER, MONOHYDROCHLORIDE-->Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate-->4'-(aminometil)bifenil-2-karbonitril |
Baj popilè: 4-bromomethyl-2-cyanobiphenyl, Lachin 4-bromomethyl-2-cyanobiphenyl manifaktirè, founisè, faktori
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