Pwodwi

Ethyl (R)-(-)-4-syan-3-hydroxybutyate

Pwodwi Entwodiksyon

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Enfòmasyon de baz

Non pwodwi:	Ethyl (R)-(-)-4-syan-3-hydroxybutyate
Sinonim:	(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-(-)- ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL;ETHYL (3R)-4-SYANO-3-IDROKSIBUTANOAT;ETHYL (S)-4-SYANO-3-HYDROXYBUTANOATE;ETHYL (R)-4-CYANO-3- HYDROXYBUTANOATE
CAS:	141942-85-0
MF:	C7H11NO3
mw:	157.17
EINCS:	430-220-6
Kategori pwodwi:	Atorvastatin entèmedyè;chiral;Alkòl, Ester idwoksi ak dérivés;Konpoze chiral;ENMEDIATESOFATORVASTATIN;Entèmedyè API;Entèmedyè pharmaceutique;141942-85-0
Mol File:	141942-85-0.mol

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Pwopriyete chimik

alfa	-5 º (pwòp)
Pwen bouyi	270 degre (lit.)
dansite	1.114 g/mL nan 25 degre (lit.)
endèks refraktif	n20% 2FD 1.448 (lit.)
Fp	>230 degre F
tanperati depo.	2-8 degre
solubilite	Chloroform (Ti kras), DMSO (yon ti kras), Methanol (yon ti kras)
pka	13.03±0.20(Prevwa)
fòm	Likid
Espesifik gravite	1.114
koulè	San koulè a jòn
aktivite optik	[ ]25/D 5 degre , pwòp
retni	5328715
InChiKey	LOQFROMBBSKWQY-ZCFIWIBFSA-N
Referans baz done CAS	141942-85-0(Referans baz done CAS)

Enfòmasyon sou Sekirite

Enfòmasyon MSDS

Founisè	Lang
Sigmaaldrich	angle
ALFA	angle

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Itilizasyon ak sentèz

Pwopriyete chimik	likid jòn
Itilizasyon	analgesic, antipiretik, ak anti-enflamatwa
Itilizasyon	(3R)-4-Cyano-3-hydroxybutanoic Asid Ethyl Ester yo itilize nan yon pwosesis biocatalytic pou sentèz yon entèmedyè atorvastatin ak pwodwi/enpurte degredasyon.
Aplikasyon	Hydroxyglutaryl coenzyme A (HMG-CoA) inibitè reduktaz yo se yon nouvo klas dwòg ki bese lipid, epi yo gen yon pati nan mache ki gen plis pase 10 milya dola ameriken nan jaden pharmaceutique aktyèl la. Yo ka oaza anpeche anzim ki limite pousantaj HMG-CoA reduktaz nan sentèz kolestewòl nan fwa a, diminye pwodiksyon lipoprotein fwa a, epi ogmante ekspresyon reseptè kolestewòl lipoprotein ba-dansite (LDL), kidonk diminye nivo kolestewòl nan plasma. Yo kapab tou siyifikativman redwi lipoprotein trè ba-dansite (VLDL) ak trigliserid, epi ogmante pwoteyin anti-ateroskleroz segondè-dansite (HDL), anpeche ateroskleroz ak maladi kè kardyovaskulèr. Ethyl (R)-(-)-4-cyano-3-hydroxybutyate se yon entèmedyè enpòtan pou sentèz inhibiteurs HMG-CoA reduktaz. Si li itilize kòm yon matyè premyè, atorvastatin sentetik se sitou itilize pou tretman ipèkolesterolemi ak ipèrlipidemi melanje, maladi kè kardyovaskulèr ak konjesyon serebral.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparasyon pwodwi ak matyè premyè

Matyè premyè	Butanoic acid, 4-cyano-3-hydroxy-, (3R)--->Ethyl 4-bromo-3-hydroxybutyrate-->Sodium cyanide-->Ethanol-->Ethyl 4-chloroacetate
Preparasyon pwodwi yo	(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic asid tert-butyl Ester

Baj popilè: etil (r)-(-)-4-syan-3-hydroxybutyate, Lachin etil (r)-(-)-4-cyano-3-hydroxybutyate manifaktirè, founisè, faktori

On: Non

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