Pwodwi Entwodiksyon
| 6-methoxy-1-tetralone Enfòmasyon de baz |
| Non pwodwi: | 6-metoksi-1-tetralon |
| Sinonim: | 6-METOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YON;6-METOXY{-1,2,3,4- TETRAIDRO-1-NAFTALENÒN;6-METOXY{-1,2,3,4-TETRAIDRO-1-NAFTÒN;6-METOXY-3,{ {20}}DIHYDRO-2H-NAPHTHALEN-1-YON;6-METOXY-1-TETRALONE;6-METOXY TETRALONE;6-METOXY-ALPHA- TETRALONE;TIMTEC-BB SBB007549 |
| CAS: | 1078-19-9 |
| MF: | C11H12O2 |
| mw: | 176.21 |
| EINCS: | 214-078-0 |
| Kategori pwodwi: | Ketonn; C11 a C12; Konpoze kabònil; Konpoze kabònil; Ketonn |
| Mol File: | 1078-19-9.mol |
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| 6-methoxy-1-tetralone Pwopriyete Chimik |
| Pwen k ap fonn | 77-79 degre (lit.) |
| Pwen bouyi | 171 degre / 11 mmHg (limen) |
| dansite | 1.0558 (estimasyon ki graj) |
| endèks refraktif | 1.5250 (estimasyon) |
| Fp | 171 degre / 11mm |
| tanperati depo. | Sele nan sèk, Tanperati chanm |
| fòm | Fine Crystalline Powder |
| koulè | Jòn a mawon limyè |
| PH | 5.96 nan 23 degre ak 10g / L |
| Mèkredi | 14,6000 |
| retni | 972739 |
| InChiKey | MNALUTYMBUBKNX-UHFFFAOYSA-N |
| Referans baz done CAS | 1078-19-9(Referans baz done CAS) |
| Referans Chimi NIST | 1(2H)-naftalenon, 3,4-diidro-6-metoksi-(1078-19-9) |
| Sistèm Rejis Sibstans EPA | 1(2H)-naftalenon, 3,4-diidro-6-metoksi- (1078-19-9) |
| Enfòmasyon sou Sekirite |
| Kòd danje | Xn, Xi |
| Deklarasyon Risk | 22-36/37/38-20/21/22 |
| Deklarasyon Sekirite | 24/25-36-26 |
| WGK Almay | 3 |
| Nòt danje | Iritant |
| tSCA | Wi |
| Kòd HS | 29145000 |
| Enfòmasyon MSDS |
| Founisè | Lang |
|---|---|
| 6-Methoxytetralone | angle |
| Sigmaaldrich | angle |
| ATRAVÈ | angle |
| ALFA | angle |
| 6-methoxy-1-tetralone Itilizasyon ak sentèz |
| Pwopriyete chimik | jòn nan limyè mawon amann poud cristalline |
| Itilizasyon | 6-Metoksi-1-tetralon se yon reyaktif ki itil nan sentèz (2-(furanyl)vinyl)-1-tetralone chalcones ki genyen ajan antikansè ak pwodiktè apoptoz. |
| Definisyon | ChEBI: 6-Methoxy-1-tetralone se yon manm nan tetralins. |
| Preparasyon | (1) Anisol reyaji ak yon ajan acilating nan asid Lewis ak yon sòlvan nan tanperati -10-40 degre pou jenere yon entèmedyè 1, kote rapò molè asid Lewis ak ajan acylation ak anisol la se {{3 }}: 1-10: 1, asid Lewis la chwazi nan youn oswa plis nan asid silfirik konsantre, asid fosfò, asid polifosfò, klori zenk, triklori aliminyòm, superasid ak asid heteropoly; (2) entèmedyè 1 a pa bezwen separe, tanperati a ogmante a 70-120 degre, epi entèmedyè 1 a kontinye reyaji pou jenere 6-methoxy-1-tetralone; (3) refwadisman pwodwi reyaksyon an, ajoute dlo pou sispann reyaksyon an, èkstraksyon, pirifye ak desolvantizasyon pou jwenn yon pwodwi brit nan 6-methoxy-1-tetralone, ak rafine pwodwi brit la pa yon sòlvan pou jwenn yon pwodwi pite segondè. |
| Referans sentèz (yo) | Journal of American Chemical Society, 64, p. 94, 1942DOI:10.1021/ja01253a025 Tetrahedron Letters, 9, p. 2917, 1968DOI: 10.1016/S0040-4039(00)89611-2 |
| Sentèz | Sentèz {{0}}methoxy-1-tetralone se jan sa a: reyaktif Eaton a (1.00 mL, 5.31 mmol) te ajoute tou dousman nan yon solisyon methyl {{6}. }}(3-methoxyphenyl)butanoate (4; 0.37g, 1.78 mmol) nan DCE (1 mL). Melanj ki te lakòz yo te brase nan 75 degre pou 2 èdtan anba N2atmosfè. Lè sa a, yo te pèmèt melanj reyaksyon an rive nan tanperati chanm, epi yo te vide sou glas dlo ak ekstrè ak EtOAc (3 × 15 mL). Ekstrè òganik konbine yo te lave youn apre lòt ak sèl (2 × 15 mL) ak H2O (2 × 20 mL), filtre sou Na2KONSA4ak konsantre anba presyon redwi. Lwil mawon ki te lakòz yo te fraksyon nan kolòn kwomatografi (jèl silica, EtOAc-hexanes, 1:9) pou jwenn 6-methoxy-1-tetralone kòm lwil jòn; sede: 0.28 g (91%). |
| 6-methoxy-1-pwodwi preparasyon tetralon ak matyè premyè |
| Matyè premyè | FUMING SULFURIC ACID-->Detergent-->6-METOXY-1,2,3,4-TETRAIDRONAFTALEN |
| Preparasyon pwodwi yo | 17-Ethinyl-17-hydroxy-18-methylestra-5(10),9(11)-dien-3-one-3-ethylene ketal-->3-Methoxy-18-methylestra-2,5(10)dien-17-one 17-ethylene ketal-->17-Ethinyl-3,17-dihydroxy-18-methylestra-2,5(10)-diene3-methylether-->3-Methoxy-18-methylestra-1,3,5(10),8-tetraen-17-ethylene ketal-->6-CYANO-1-TETRALONE-->6-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one-->4-Methoxyphthalic acid-->2-Methoxy-6,7,8,9-tetrahydrobenzocyclohepten-5-one-->2-[2-(6-methoxytetralin-1-ylidene)-ethyl]-2-methylcyclopentane-1,3-dione -->1-CHLORO-6-METHOXY-3,4-DIHYDRO-NAPHTHALENE-2-CARBALDEHYDE-->7-METOXY-4,5-DIHYDRO-NAPHTHO[1,2-D]TIAZOL-2-ILAMINE |
Baj popilè: 6-methoxy-1-tetralone, Lachin 6-methoxy-1-tetralone manifaktirè, founisè, faktori
Pwochen: 4'-Hydroxyacetophenone
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