Pwodwi Entwodiksyon
| Methyl cyanoacetate Enfòmasyon de baz |
| Deskripsyon |
| Non pwodwi: | Methyl cyanoacetate |
| Sinonim: | 2-cyanopropanoate;Tofacitinib Enpurte 198;Pemetrexed disodium Impurety 12;25KG,100KG,1T;Methyl cyanoethanoate;methyl2-cyanoacetate;methylcyanoethanoate;Methylester kyseliny kyanoctove |
| CAS: | 105-34-0 |
| MF: | C4H5NO2 |
| mw: | 99.09 |
| EINECS: | 203-288-8 |
| Kategori pwodwi: | pwodui chimik òganik; Piperazin; C2 a C5; Konpoze Carbonyl; Estè |
| Mol File: | 105-34-0.mol |
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| Methyl cyanoacetate Pwopriyete Chimik |
| Pwen k ap fonn | -13 degre |
| Pwen bouyi | 204-207 degre (lit.) |
| dansite | 1.123 g/mL nan 25 degre (lit.) |
| dansite vapè | 3.41 (kont lè) |
| presyon vapè | 0.2 mm Hg (20 degre) |
| endèks refraktif | n20/D 1.417(lit.) |
| Fp | >230 degre F |
| tanperati depo. | Sele nan sèk, Tanperati chanm |
| solubilite | 54g/l |
| fòm | Likid |
| pka | 2.75±0.10(Prevwa) |
| koulè | Klè san koulè a yon ti kras jòn |
| Solibilite dlo | 54 g/L (20 ºC) |
| Sansib | Limyè sansib |
| BRN | 773945 |
| Konstan Dielectric | 29.4 (21 degre) |
| LogP | -0.47 nan 25 degre |
| Referans baz done CAS | 105-34-0(Referans baz done CAS) |
| Referans Chimi NIST | Asid acetic, cyano-, methyl ester (105-34-0) |
| Sistèm Rejis Sibstans EPA | Asid acetic, cyano-, methyl ester (105-34-0) |
| Enfòmasyon sou Sekirite |
| Kòd danje | ksi |
| Deklarasyon Sekirite | 24/25 |
| WGK Almay | 1 |
| RTECS | AG4375000 |
| Nòt danje | Iritant |
| TSCA | Wi |
| Kòd HS | 29269095 |
| Toksisite | kochon Gine,LDLo,po,400mg/kg (400mg/kg),"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prag, Tchekoslovaki, Avicenum, 1986Vol. -, paj. 920, 1986. |
| Enfòmasyon MSDS |
| Founisè | Lang |
|---|---|
| Methyl cyanoacetate | angle |
| SigmaAldrich | angle |
| ACROS | angle |
| ALFA | angle |
| Methyl cyanoacetate Itilizasyon ak sentèz |
| Deskripsyon | Methyl cyanoacetate se pwodwi entèmedyè nan sentèz òganik pharmaceutique kòm byen ke nan sentèz kèk konpoze byolojik aktif yo itilize nan agrikilti. Li ka itilize nan sentèz divès kalite 1,2,5-trikarbonil konpoze. Li se souvan itilize kòm yon nukleofil nan oksidasyon elektwochimik nan katechol. Methyl Cyanoacetate se tou yon reyaktif nan sentèz Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate; yon konpoze ki itilize nan sentèz inhibiteurs DPP-IV pou trete dyabèt tip-2. Anplis de sa, li se yon entèmedyè nan preparasyon -cyanoacrylate, malononitrile, ak koloran asid 1,1-cyclohexanediacetic. Li se itilize kòm UV absòbe oswa estabilize, entèmedyè pou edikaman. Li ka itilize nan sentèz divès kalite 1,2,5-trikarbonil konpoze. |
| Pwopriyete chimik | klè san koulè a trè ti kras jòn likid |
| Itilizasyon | entèmedyè pharmaceutique |
| Itilizasyon | Methyl cyanoacetate se yon entèmedyè nan preparasyon -cyanoacrylate, malononitrile, 1,1-cyclohexanediacetic asid lank. Li se itilize kòm UV absòbe oswa estabilize, entèmedyè pou edikaman. Li ka itilize nan sentèz divès kalite konpoze 1,2,5-tricarbonyl. |
| Definisyon | ChEBI: Methyl cyanoacetate se yon ester alkyl cyanoacetate. |
| Deskripsyon jeneral | Methyl cyanoacetate se pwodwi entèmedyè nan sentèz òganik pharmaceutique kòm byen ke nan sentèz kèk konpoze byolojik aktif yo itilize nan agrikilti. Li sibi kalsit oswa fliyorit katalize Kn?venagel kondansasyon ak aldehydes aromat, bay arylidenemalononitriles korespondan yo ak (E)- -estè cyanocinnamic. |
| Metòd pou pirifye | Pirifye ester la pa souke ak 10% solisyon Na2CO3, lave byen ak dlo, sèk ak Na2SO4 anidrid, epi distile li. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.] |
| Methyl cyanoacetate Preparasyon pwodwi ak matyè premyè |
| Matyè premyè | Ethyl cyanoacetate-->Sodium cyanide-->Methyl chloroacetate |
| Preparasyon pwodwi yo | 2-Cyanoacetamide-->Buspirone-->2,2-Dibromo-2-cyanoacetamide-->METHYL 2-AMINO-4-PHENYLTHIOPHENE-3-CARBOXYLATE-->2-AMINO-5-ETHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER-->METHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE-->5-AMINO-3-METHYL-THIOPHENE-2,4-DICARBOXYLIC ACID DIMETHYL ESTER-->2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER-->Solvent Red 196-->CYANOACRYLIC ACID METHYL ESTER-->Minoxidil-->2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER-->4-Chloro-2,6-diaminopyrimidine-->2-AMINO-4-ETHYL-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER-->Methyl 2-aminothiophene-3-carboxylate-->2,4-Diamino-6-hydroxypyrimidine-->METHYL 2-CHLORONICOTINATE-->4-Amino-6-chloropyrimidine-->BASIC YELLOW 40-->N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone-->methyl 2-cyano-3-ethoxyacrylate-->2-CYANO-2-PROPYLPENTANOATE METHYL |
Baj popilè: methyl cyanoacetate, Lachin methyl cyanoacetate manifaktirè, Swèd, faktori
Pwochen: Cyanoacetate etil
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