Pwodwi Entwodiksyon
| 1-Tetralone enfòmasyon de baz |
| Non pwodwi: | 1-Tetralone |
| Sinonim: | KETOTETRAHYDRONAPHTHALENE;A-TETRALONE;1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE;1-TETRALONE;3,4-DIHYDRO-2H-NAPHTHALEN{{ 11}}YON;3,4-DIIDRO-1-(2H)NAFTALENÒN;3,4-DIIDRO-1(2H)-NAFTALENÒN;ALFA-TETRALÒN |
| CAS: | 529-34-0 |
| MF: | C10H10O |
| mw: | 146.19 |
| EINECS: | 208-460-6 |
| Kategori pwodwi: | Ti Molekil Bioaktif; Blòk Konstriksyon; C10; Konpoze Carbonyl; Biyoloji Selil; Sentèz Chimik; FARMACEUTIK INTERMEDIATE; Ketonn; Blòk Konstriksyon òganik; T; Ajan Kadyovaskilè ak Sistèm San; pharmaceutique; bc0001;529-34-0 |
| Mol File: | 529-34-0.mol |
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| 1-Tetralone Pwopriyete Chimik |
| Pwen k ap fonn | 2-7 degre (lit.) |
| Pwen bouyi | 113-116 degre 6 mm Hg(lit.) |
| dansite | 1.099 g/mL nan 25 degre (limen) |
| endèks refraktif | n20/D 1.568(lit.) |
| Fp | >230 degre F |
| tanperati depo. | 2-8 degre |
| solubilite | Kloròfòm, Acetate etil (yon ti kras) |
| fòm | Likid |
| koulè | mawon |
| Solibilite dlo | ensolubl |
| BRN | 607374 |
| InChiKey | XHLHPRDBBAGVEG-UHFFFAOYSA-N |
| Referans baz done CAS | 529-34-0(Referans baz done CAS) |
| Referans Chimi NIST | 1(2H)-naftalenon, 3,4-diidro-(529-34-0) |
| Sistèm Rejis Sibstans EPA | 1,2,3,4-Tetrahydronaphthalen-1-yon sèl (529-34-0) |
| Enfòmasyon sou Sekirite |
| Kòd danje | Xn |
| Deklarasyon Risk | 22-20/22-20/21/22 |
| Deklarasyon Sekirite | 23-24/25-36 |
| WGK Almay | 3 |
| RTECS | QK4375000 |
| TSCA | Wi |
| Kòd HS | 29143900 |
| Done Sibstans Danjre yo | 529-34-0(Done Sibstans Danjere) |
| Toksisite | LD50 oralman nan lapen: 810 mg/kg LD50 po lapen > 2200 mg/kg |
| Enfòmasyon MSDS |
| Founisè | Lang |
|---|---|
| 1-Tetralone | angle |
| SigmaAldrich | angle |
| ACROS | angle |
| ALFA | angle |
| 1-Itilizasyon ak sentèz Tetralone |
| Pwopriyete chimik | Klè amber a mawon likid lwil |
| Itilizasyon | 1-Tetralone se yon reyaktif ki itilize nan sentèz amino-pirazolopiridin ak anti-NF-κB ak potansyèl pro-apoptotik. |
| Referans sentèz (yo) | Tetrahedron Letters, 32, p. 4291, 1991DOI: 10.1016/S0040-4039(00)92151-8 |
| Metòd pou pirifye | Tcheke IR a an premye. Pirifye -tetralone pa fonn 20mL nan Et2O (200mL), lave ak H2O (100mL), 5% akeuz NaOH (100mL), H2O (100mL), 3% akeuz AcOH (100mL). ), 5% NaHCO3 (100mL) Lè sa a, H2O (100mL) epi sèk kouch eterik la sou MgSO4. Filtre, evapore ak fraksyon nan yon kolòn Vigreux 6 pous (p 11) anba presyon redwi pou bay yon lwil san koulè (~17g) ak b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] Li te tou fraksyon nan yon kolòn chaje 0.5mèt ak yon jakèt chofe anba rflu lè l sèvi avèk yon tèt dekole pasyèl. Li gen max 247.5 ak 290nm (hexane). Fenilhydrazone a gen m 83o. 2,4,6-trinitrophenylhydrazone a gen m 247.5-248o (soti nan EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.] |
| 1-Pwodwi Preparasyon Tetralone Ak Matyè Bwit |
| Matyè premyè | Aluminum chloride-->Hydrogen fluoride-->Polyphosphoric acid-->Phosphorus pentoxide-->Tin tetrachloride-->Butyryl chloride-->Gamma Butyrolactone-->4-Phenylbutyric acid-->1,2,3,4-Tetrahydronaphthalene-->5-Ethyl-2-methylpyridine-->Chromic acetate-->1(2H)-Naphthalenone, 3,4-dihydro-, 2,2-dimethylhydrazone-->(4,4-Difluoro-3-buten-1-yl)benzene-->4-Klori fenilbutiril |
| Preparasyon pwodwi yo | (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid-->γ-Hydroxybutyrophenone-->7-Hydroxy-1-tetralone-->2,3-Dihydro-1,4-naphthoquinone-->(S)-(+)-1,2,3,4-Tetrahydro-1-naftol |
Baj popilè: 1-tetralone, Lachin 1-tetralone manifaktirè, founisè, faktori
Pwochen: 6-Bromoveratraldehyde
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